Essentials: Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson
In this Huberman Lab Essentials episode, my guest is Dr. Matthew Johnson, PhD, a senior researcher for the Center of Excellence for Psilocybin Research and Treatment at Sheppard Pratt’s Institute for Advanced Diagnostics and Therapeutics.
July 24, 2025
39 min
Full
321 of 417

July 24, 2025
Essentials: Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson
0:00 / 39:09
Excerpt playback isn’t available for this episode — use the full-episode link.
Search the Record
Moment search isn’t open for this episode yet
When it opens, you’ll be able to type any phrase and jump straight to the second it was said.
Andrew Huberman Episodes Around July 24, 2025
Episode 321 of 417 — walk the feed in the order it was published.
39:09This episodeEssentials: Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson
Summary
In this Huberman Lab Essentials episode, my guest is Dr. Matthew Johnson, PhD, a senior researcher for the Center of Excellence for Psilocybin Research and Treatment at Sheppard Pratt’s Institute for Advanced Diagnostics and Therapeutics.
We explore the science and therapeutic potential of psychedelic medicine, including psilocybin, MDMA and LSD. We discuss how these substances can profoundly alter perception and self-identity, providing long-lasting relief from depression, addiction and trauma when used in controlled clinical settings. We also discuss microdosing and emerging research on psychedelics’ potential to support recovery from neurological injuries.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
David: https://davidprotein.com/huberman
BetterHelp: https://betterhelp.com/huberman
Timestamps
00:00:00 Matthew Johnson; Psychedelics
00:01:44 Different Classes of Psychedelics
00:04:33 Psychedelics & Altering Models
00:06:18 Sponsor: David
00:07:33 LSD, Psylocibin & Serotonin
00:09:55 Psychedelic Clinical Trials
00:13:40 Therapy, Trust, Psychedelics
00:16:47 Letting Go & Psychedelic Experience, Self-Representation, Lasting Changes
00:22:31 Sponsors: AG1 & BetterHelp
00:25:26 MDMA, Dopamine & Serotonin; Bad Trips & Transcendental Experience
00:28:49 Dangers of Psychedelics
00:31:11 Microdosing Psychedelics, Antidepressant
00:35:27 Head Injuries, Psychedelics, Depression
00:38:29 Acknowledgements
Disclaimer & Disclosures
Learn more about your ad choices. Visit megaphone.fm/adchoices
Episode details and artwork are published by the show’s own feed. Sentinel plays short cited excerpts and links every episode back to its publisher.














