% lethal rate SARS virus

Virus being experimented on in China.

https://www.researchgate.net/publication/377199018_Lethal_Infection_of_Human_ACE2-Transgenic_Mice_Caused_by_SARS-CoV-2-related_Pangolin_Coronavirus_GX_P2Vshort_3UTR

https://www.biorxiv.org/content/10.1101/2024.01.03.574008v1.full.pdf

https://www.theepochtimes.com/health/chinese-scientists-reveal-experiments-with-virus-100-percent-fatal-to-mice-5560854?utm_source=atcn&utm_content=hw1016multicomp&utm_medium=email&utm_campaign=atc&utm_term=hws1comp

SARS-CoV-2-related pangolin coronavirus GX_P2V,

can cause 100% mortality in human ACE2-transgenic mice,

potentially attributable to late-stage brain infection.

Paper Authors

Beijing Advanced Innovation Center

Beijing University of Chemical Technology,

The Fifth Medical Center of PLA General Hospital, Beijing, China.

Medical School, Nanjing University, China

(including a doctor trained by the Chinese military, Yigang Tong)

Purpose of study

Assessed virus pathogenicity

Risk

100% IFR underscores a spillover risk of GX_P2V into humans,

and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses.

Details

GX_P2V isolate was actually a cell culture-adapted mutant

In this study, we cloned this mutant

This is not a wild type virus

It is possible that GX_P2V C7 has undergone a virulence-enhancing mutation.

GX_P2V is capable of rapid mutation rates.

High viral loads detected in both lung and brain tissues.

Surprisingly, all the mice that were infected with the live virus succumbed to the infection within 7-8 days post-inoculation,

Resulted in 100% mortality in the hACE2 mice.

Clinical features

Weight loss, Piloerection, hunched posture, sluggish movements, and their eyes turned white.

Significant amounts of viral RNA in the brain, lung, turbinate, eye, trachea, reducing with time

Infection did not lead to significant inflammatory reactions or cytokine storm

Brain with high viral counts increasing during infection

ACE2 receptors are found in the human brain

Brainstem (especially areas regulating breathing and cardiovascular control)

Hypothalamus

Substantia nigra

Cortex (low levels)

Endothelial cells lining cerebral blood vessels

Some neurons and glial cells

The choroid plexus

Justin Kinney, associate professor, Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, U.S.