My first clinical Trial: 5-ALA & Glioblastoma re-irradiation
For the first time, investor Guy Spier steps outside the world of finance to share a deeply personal conversation—with the doctors who treated him. Recorded at the University Hospital Münster, this discussion with neurosurgeon Dr. Michael Müther and radiation oncologist Dr. Niklas Pepper explores the frontiers of brain cancer treatment, focusing on glioblastoma and a groundbreaking clinical trial combining 5-ALA (Gliolan®) with radiotherapy. Topics covered: What glioblastoma is and why it’s so difficult to treat The Stupp protocol and why recurrence is common How 5-ALA fluorescence surgery helps surgeons “see” tumors The role and evolution of radiotherapy and re-irradiation A new approach: radiodynamic therapy (5-ALA + radiation) How clinical trials work (Phase I, dose escalation, safety focus) Why patient participation is critical to medical progress The conversation also explores the human side of medicine: Should patients deeply engage with their disease—or not? The role of mindset, movement, and psycho-oncology How doctors balance research, clinical care, and uncertainty This is a rare, candid look at how modern medicine advances—from lab to patient—and the people behind it. Chapters: 00:00 Introduction 03:10 What is glioblastoma? 06:00 5-ALA and fluorescence-guided surgery 12:37 Radiotherapy explained 17:39 Re-irradiation and treatment evolution 23:50 The new clinical trial (radiodynamic therapy) 35:48 How clinical trials work (Phase I, dose escalation) 45:39 Collaboration in cancer research 53:32 Why Germany leads in this field 59:03 Patient involvement in research 01:01:41 The psychology of disease 01:06:32 Final thoughts Transcript to the whole episode is available here: https://aqfd.docsend.com/view/5gbyupsrddq9ieda Disclaimer: Nothing contained herein constitutes or should be construed as medical advice. No representations or warranties are made regarding the accuracy or completeness of the information, and it should not be used as a substitute for consultation with a licensed healthcare provider.
April 23, 2026
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Episode 59 · April 23, 2026
My first clinical Trial: 5-ALA & Glioblastoma re-irradiation
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Guy Spier Episodes Around April 23, 2026
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1:12:01This episodeMy first clinical Trial: 5-ALA & Glioblastoma re-irradiation
Summary
For the first time, investor Guy Spier steps outside the world of finance to share a deeply personal conversation—with the doctors who treated him.
Recorded at the University Hospital Münster, this discussion with neurosurgeon Dr. Michael Müther and radiation oncologist Dr. Niklas Pepper explores the frontiers of brain cancer treatment, focusing on glioblastoma and a groundbreaking clinical trial combining 5-ALA (Gliolan®) with radiotherapy.
Topics covered:
What glioblastoma is and why it’s so difficult to treat
The Stupp protocol and why recurrence is common
How 5-ALA fluorescence surgery helps surgeons “see” tumors
The role and evolution of radiotherapy and re-irradiation
A new approach: radiodynamic therapy (5-ALA + radiation)
How clinical trials work (Phase I, dose escalation, safety focus)
Why patient participation is critical to medical progress
The conversation also explores the human side of medicine:
Should patients deeply engage with their disease—or not?
The role of mindset, movement, and psycho-oncology
How doctors balance research, clinical care, and uncertainty
This is a rare, candid look at how modern medicine advances—from lab to patient—and the people behind it.
Chapters:
00:00 Introduction
03:10 What is glioblastoma?
06:00 5-ALA and fluorescence-guided surgery
12:37 Radiotherapy explained
17:39 Re-irradiation and treatment evolution
23:50 The new clinical trial (radiodynamic therapy)
35:48 How clinical trials work (Phase I, dose escalation)
45:39 Collaboration in cancer research
53:32 Why Germany leads in this field
59:03 Patient involvement in research
01:01:41 The psychology of disease
01:06:32 Final thoughts
Transcript to the whole episode is available here: https://aqfd.docsend.com/view/5gbyupsrddq9ieda
Disclaimer:
Nothing contained herein constitutes or should be construed as medical advice. No representations or warranties are made regarding the accuracy or completeness of the information, and it should not be used as a substitute for consultation with a licensed healthcare provider.
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