Introducing 1-MNA: The New Longevity Molecule With Lisa Tamati

<p>In this episode, we delve into a revolutionary longevity molecule that you might not have heard of before: 1-MNA. If you're interested in staying younger longer and if you want to maintain your energy and vitality then this is an episode for you.</p> <p>Perhaps you have read the groundbreaking book by Dr David Sinclair "Lifespan" where he talks about NAD and how crucial it is for the body and how it can help upregulate sirtuin genes (longevity genes) and help you maintain your cellular health and energy. We are now 4 years on we have more data, studies and information to share in this arena.</p> <p>Perhaps you have been trying to improve  your NAD metabolism, taking NMN (nicotinamide mononucleotide)  or NR (nicotinamide riboside), and upregulating sirtuin genes, if you have then you need to hear this.</p> <p> We'll explore the intricacies of NAD pathways, the role of key enzymes, and why simply supplementing with NAD precursors may not be the best holistic approach and how we can improve on that approach to anti-aging</p> <p><strong>Key Points Discussed:</strong></p> <ol> <li> <p><strong>Introduction to NAD Metabolism:</strong></p> <ul> <li>Overview of previous episodes on NAD metabolism with experts like <a href="https://www.youtube.com/watch?v=ua04Lv5x9ms" rel="noopener noreferrer" target="_blank">Professor Joseph Baur</a>, <a href="https://youtu.be/7IjXBi5PM24" rel="noopener noreferrer" target="_blank">Dr. Elizabeth Yurth</a> from the Boulder Longevity Institute, and <a href="https://youtu.be/h18r7pZ2wUY" rel="noopener noreferrer" target="_blank">Dr. Elena Seranova.</a></li> <li>Importance of understanding the complexities of NAD pathways beyond the basics.</li> </ul> </li> <li> <p><strong>Understanding 1-MNA:</strong></p> <ul> <li>Explanation of 1-MNA and its role in controlling NAD levels by blocking the enzyme NNMT (Nicotinamide N-methyltransferase).</li> <li>The dangers of upregulating NNMT, which degrades NAD and can lead to various health issues.</li> </ul> </li> <li> <p><strong>Key Enzymes in NAD Metabolism:</strong></p> <ul> <li>Discussion on the salvage pathway and two critical enzymes that degrade NAD.</li> <li>Importance of regulating NNMT to prevent its deleterious effects, particularly in senescent cells, cancer cells, and fat cells.</li> </ul> </li> <li> <p><strong>Benefits of 1-MNA</strong></p> <ul> <li>How 1-MNA can help maintain a balanced NAD metabolism by inhibiting NNMT.</li> <li>Potential benefits for conditions like schizophrenia, neurodegeneration, liver diseases, and cancer.</li> </ul> </li> <li> <p><strong>Research and Studies:</strong></p> <ul> <li>Overview of studies showing the positive effects of 1-MNA on post-COVID conditions, inflammation, and mitochondrial function.</li> <li>Insights from animal studies on 1-MNA's protective effects against metabolic disorders.</li> </ul> </li> <li> <p><strong>Practical Applications:</strong></p> <ul> <li>Recommendations for integrating 1-MNA into supplement regimens, especially for those taking NMN or NR.</li> <li>Potential benefits for various conditions, including obesity, metabolic syndrome, cardiac disease, liver disease, cancer risk, long COVID, and fatigue.</li> </ul> </li> <li> <p><strong>Balancing NAD Levels:</strong></p> <ul> <li>Importance of maintaining NAD levels for energy production, DNA repair, neurotransmitter health, and longevity.</li> <li>The role of NAD as a redox molecule and the balance between NAD+ and NADH.</li> </ul> </li> <li> <p><strong>Conclusion:</strong></p> <ul> <li>Encouragement to explore further research on NNMT and its impact on health.</li> <li>Final thoughts on the potential of 1-MNAas a crucial supplement for maintaining NAD balance and promoting longevity.</li> </ul> </li> </ol> <p><strong>References and Links:</strong></p> <ul> <li>Boulder Longevity Institute: <a href="https://boulderlongevity.com/" rel="noopener noreferrer" target="_blank">https://boulderlongevity.com/</a></li> <li>SSRP Institute: <a href="https://ssrpinstitute.org/" rel="noopener noreferrer" target="_blank">https://ssrpinstitute.org/</a></li> <li>Studies on NNMT and related conditions: <a href="https://scholar.google.com/scholar?hl=en&amp;as_sdt=0%2C5&amp;q=NNMT+enzymes&amp;btnG=" rel="noopener noreferrer" target="_blank">Research</a></li> </ul> <div> </div> <ul> <li>If you enjoyed this episode, please give it a like, share, and subscribe to the YouTube channel.</li> <li>Tune in weekly for more interviews with top doctors and scientists on health optimization and longevity.</li> </ul> <div><strong>Get Your 1-MNA now</strong></div> <p><strong>If you want to start supplementing with 1-MNA to support your own healthy aging journey, to upregulate your NAD metabolism, support sirtuin genes and prevent the overexpression of the deleterious NNMT Enzyme you can buy it here: <a href="https://shop.lisatamati.com/products/endotelio-1-mna-30-caps?_pos=1&amp;_sid=6095f0c9f&amp;_ss=r" rel="noopener noreferrer" target="_blank">1-MNA</a> and use code NAD to get $25 off your first order</strong></p> <ul> <li>Stay up-to-date with the latest research and evolve with the science to optimize your health and longevity. See you in the next episode!</li> </ul> <div> <div class="v1gmail_signature" dir="ltr"> <div dir="ltr"> <div dir="ltr"> <div dir="ltr"> <div dir="ltr"> <div dir="ltr"> <div> <div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <p class="p-font"> </p> <p class="p-font"> </p> <p class="p-font"><strong>Personalised Health Optimisation Consulting with Lisa Tamati</strong></p> <p class="p-font">Lisa offers solution focused coaching sessions to help you find the right answers to your challenges.</p> <p class="p-font"><br /> <br /></p> <p class="p-font">Topics Lisa can help with: </p> <p class="p-font">Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach.</p> <p class="p-font">She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking.</p> <p class="p-font">She has extensive knowledge on such therapies as hyperbaric oxygen,  intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing.</p> <p class="p-font"><strong>Testing Options</strong></p> <ul> <li> <p class="p-font">Comprehensive Thyroid testing</p> </li> <li> <p class="p-font">DUTCH Hormone testing</p> </li> <li> <p class="p-font">Adrenal Testing</p> </li> <li> <p class="p-font">Organic Acid Testing</p> </li> <li> <p class="p-font">Microbiome Testing</p> </li> <li> <p class="p-font">Cell Blueprint Testing</p> </li> <li> <p class="p-font">Epigenetics Testing</p> </li> <li> <p class="p-font">DNA testing</p> </li> <li> <p class="p-font">Basic Blood Test analysis</p> </li> <li> <p class="p-font">Heavy Metals </p> </li> <li> <p class="p-font">Nutristat</p> </li> <li> <p class="p-font">Omega 3 to 6 status</p> </li> </ul> <p class="p-font">and more <br /> <br /> <br /> <br /></p> <p class="p-font">Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine .</p> <p class="p-font">She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the  challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. <a href="https://shop.lisatamati.com/collections/consultations" rel="noopener" target="_blank" type="website">Book your consultation with Lisa</a> </p> <p class="p-font"> </p> <p class="p-font"><strong>Join our Patron program and support the show</strong></p> <p class="p-font">Pushing the Limits' has been free to air for over 8 years. 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But we need help on our mission. </p> <p class="p-font">Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two</p> <p class="p-font">You can join by going to  <a href="https://www.patreon.com/LisaT" rel="noopener" target="_blank" type="website">Lisa's Patron Community</a></p> <p class="p-font">Or if you just want to support Lisa with a "coffee" go to </p> <p class="p-font"><a href="https://www.buymeacoffee.com/LisaT" rel="noopener" target="_blank" type="website">https://www.buymeacoffee.com/LisaT</a> to donate $3</p> <p class="p-font"> </p> <p class="p-font"><strong>Lisa's Anti-Aging and Longevity Supplements</strong> </p> <p class="p-font">Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world. </p> <p class="p-font">This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life.</p> <p class="p-font"> </p> <p class="p-font"><strong>Subscribe to our popular Youtube channel</strong> </p> <p class="p-font">with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel.</p> <p class="p-font"><a href="https://www.youtube.com/user/lisatamat" rel="noopener" target="_blank" type="website">Youtube</a></p> <p class="p-font"> </p> <p class="p-font"><strong>Order Lisa's Books</strong></p> <p class="p-font">Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge" </p> <p class="p-font">Check them all out at </p> <p class="p-font"><a href="https://shop.lisatamati.com/collections/books" rel="noopener" target="_blank" type="website">https://shop.lisatamati.com/collections/books</a></p> <p class="p-font"> </p> <p class="p-font"><strong>Perfect Amino Supplement by Dr David Minkoff</strong></p> <p class="p-font">Introducing PerfectAmino</p> <ul> <li> <p class="p-font">PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein.</p> </li> <li> <p class="p-font">PerfectAmino is 3-6x the protein of other sources with almost no calories.</p> </li> <li> <p class="p-font">100% vegan and non-GMO.</p> </li> <li> <p class="p-font">The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily.</p> </li> <li> <p class="p-font">Fully absorbed within 20-30 minutes!</p> </li> <li> <p class="p-font">No other form of protein comes close to <a href="https://runninghotcoaching.com/homepage" rel="noopener" target="_blank" type="website">PerfectAminos</a><br /> <br /> <br /></p> </li> </ul> <p class="p-font">Listen to the episode with <a href="https://www.lisatamati.com/podcast--dr-david-minkoff/" rel="noopener" target="_blank" type="website">Dr Minkoff here:</a> </p> <p class="p-font"><strong> </strong></p> <p class="p-font">Use code "tamati" at checkout to get a 10% discount on any of their devices.</p> <p class="p-font"><strong> </strong></p> <p class="p-font"><strong>Red Light Therapy:</strong></p> <p class="p-font">Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try</p> <p class="p-font">Flexbeam: A wearable Red Light Device</p> <p class="p-font"><a href="https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38" rel="noopener" target="_blank" type="website">https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38</a></p> <p class="p-font"> </p> <p class="p-font">Or Try Vielights' advanced Photobiomodulation Devices</p> <p class="p-font">Vielight brain photobiomodulation devices combine electrical engineering and neuroscience.</p> <p class="p-font">To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to</p> <p class="p-font"><a href="http://www.vielight.com/" rel="noopener" target="_blank" type="website">www.vielight.com</a> and use code "tamati" to get 10% off</p> <p class="p-font"> </p> <p class="p-font"> </p> <p class="p-font"><strong>Enjoyed This Podcast?</strong></p> <p class="p-font">If you did, subscribe and share it with your friends!</p> <p class="p-font">If you enjoyed tuning in, then leave us a review and share this with your family and friends.</p> <p class="p-font">Have any questions? You can contact my team through email (<a href="mailto:support@lisatamati.com" rel="noopener" target="_blank" type="website">support@lisatamati.com</a>) or find me on <a href="https://www.facebook.com/lisatamati/" rel="noopener" target="_blank" type="website">Facebook</a>, <a href="https://www.twitter.com/lisaytamati" rel="noopener" target="_blank" type="website">Twitter</a>, <a href="https://www.instagram.com/pushingthelimitspodcast/" rel="noopener" target="_blank" type="website">Instagram</a> and <a href="https://www.youtube.com/user/lisatamat" rel="noopener" target="_blank" type="website">YouTube</a>.</p> <p class="p-font">For more episode updates, visit my <a href="https://www.lisatamati.com/" rel="noopener" target="_blank" type="website">website</a>. You may also tune in on <a href="https://podcasts.apple.com/au/podcast/pushing-the-limits/id1207975008" rel="noopener" target="_blank" type="website">Apple Podcasts.</a></p> <p class="p-font"><br /> <br /></p> <p class="p-font"> To pushing the limits,</p> <p class="p-font">Lisa and team</p>