303 | James P. Allison on Fighting Cancer with the Immune System

<p>A typical human lifespan is approximately three billion heartbeats in duration. Lasting that long requires not only intrinsic stability, but an impressive capacity for self-repair. Nevertheless, things do occasionally break down, and cancer is one of the most dramatic examples of such breakdown. Given that the body is generally so good at protecting itself, can we harness our internal security patrol - the immune system - to fight cancer? This is the hope of Nobel Laureate James Allison, who works on studying the structure and behavior of immune cells, and ways to coax them into fighting cancer. This approach offers hope of a way to combat cancer effectively, lastingly, and in a relatively gentle way.</p> <p><em>Support Mindscape on </em><a href="https://www.patreon.com/seanmcarroll" rel="noopener noreferrer" target="_blank"><em>Patreon</em></a><em>.</em></p> <p>Blog post with transcript: <a href="https://www.preposterousuniverse.com/podcast/2025/01/27/303-james-p-allison-on-fighting-cancer-with-the-immune-system/" rel="noopener noreferrer" target="_blank">https://www.preposterousuniverse.com/podcast/2025/01/27/303-james-p-allison-on-fighting-cancer-with-the-immune-system/</a></p> <p>James P. Allison received his Ph.D. in biology from the University of Texas at Austin. He is currently Regental Professor and Chair of the Department of Immunology, the Olga Keith Wiess Distinguished University Chair for Cancer Research, Director of the Parker Institute for Cancer Research, and Director of the <a href="https://www.mdanderson.org/research/departments-labs-institutes/institutes/allison-institute.html" rel="noopener noreferrer" target="_blank">James P. Allison Institute</a> at MD Anderson Cancer Center. He is the subject of the documentary film <a href="https://www.uncommonproductions.com/breakthrough" rel="noopener noreferrer" target="_blank">Jim Allison: Breakthrough</a>. Among his numerous awards are the Breakthrough Prize in Life Sciences and the Nobel Prize in Physiology or Medicine.</p> <ul> <li><a href="https://faculty.mdanderson.org/profiles/james_allison.html" rel="noopener noreferrer" target="_blank">Web page</a></li> <li><a href="https://www.nobelprize.org/prizes/medicine/2018/summary/" rel="noopener noreferrer" target="_blank">Nobel Prize citation</a></li> <li><a href="https://scholar.google.com/citations?user=Vq6NVkAAAAAJ&amp;hl=en" rel="noopener noreferrer" target="_blank">Google Scholar publications</a></li> <li><a href="https://en.wikipedia.org/wiki/James_P._Allison" rel="noopener noreferrer" target="_blank">Wikipedia</a></li> </ul>