Deion Sanders full postgame press conference after Colorado's 48-41 loss to No. 8 USC

It didn't take long for Caleb Williams to realize this wasn't the same Colorado team. That Deion Sanders has brought a different vibe to the sideline, along with a host of celebrity friends.

The result was all too familiar, though — another win for Southern California.

Williams threw for 403 yards and tied a career high with six touchdown passes as the eighth-ranked Trojans held off the Buffaloes 48-41 on Saturday after racing out to a big lead.

Up 34-7 in the second quarter, the Trojans saw Colorado storm back to make it a one-score game with 1:43 remaining on Shedeur Sanders' 16-yard TD strike to Jimmy Horn Jr. The Trojans recovered the onside-kick attempt and Williams kneeled three times to close out the win.

The Trojans (5-0, 3-0 Pac-12) improved to 17-0 all-time against the Buffaloes (3-2, 0-2), who were knocked off for a second straight week after a 3-0 start that made Deion Sanders' team the biggest story in college football.

“Deion and that team, they brought a lot of energy to Colorado,” Williams said. “It's great. It's fun.”

After a two-game losing streak, Sanders insists his team is going to grow stronger.

“If you can’t see what’s coming with CU football, you’ve lost your mind,” the Buffaloes coach said. “You’re just a flat-out hater. If you can’t see what’s going on and what’s going to transpire over the next several months, something’s wrong with you.”

USC picked up right where Oregon left off last week, overwhelming the 21 1/2-point underdog Buffaloes in the first half.