Andrew Huberman
@hubermanlab·7.5M subscribers·510 videos
Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects
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May 29, 2023
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2:02:12Now PlayingIn this episode, I explain how medications such as Adderall, Ritalin, Vyvanse and other stimulants work to increase focus and treat attention-deficit/hyperactivity disorder (ADHD). I explain the brain circuits involved in focus and the key roles dopamine and norepinephrine play in their regulation. Then I explain how stimulants such as Adderall and Vyvanse can increase focus and reduce hyperactivity in kids or adults with ADHD, and how and why Ritalin and other medications (e.g., Modafinil, Guanfacine) may work better for some. I explain the long-term effects of ADHD medications on height, cardiovascular health, hormones, predisposition to addiction and psychosis, and whether these treatments can be used and then stopped. I also discuss the immense individual variation in dosage sensitivity for these medications and the negative side-effects that occur from recreational use. This episode ought to benefit anyone with ADHD, their parents, those on ADHD medications or anyone curious about how these medications work.
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Cognitive enhancement effects of stimulantsa randomized controlled trial testing methylphenidate, modafinil, and caffeine
Psychostimulants and CognitionA Continuum of Behavioral and Cognitive Activation
Neural Correlates of Symptom Improvement Following Stimulant Treatment in Adults with AttentionDeficit/Hyperactivity Disorder
Longterm effects of stimulant exposure on cerebral blood flow response to methylphenidate and behavior in attentiondeficit hyperactivity disorder
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Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD NeurobiologyA Review
Pharmacologic treatment of attention deficit hyperactivity disorder in adultsA systematic review and network metaanalysis
Books
Stahl's Essential Psychopharmacology (4th Edition)
Other Resources
Controlling Your Dopamine For Motivation, Focus & Satisfaction
Leverage Dopamine to Overcome Procrastination & Optimize Effort
ADHD & How Anyone Can Improve Their Focus
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