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Lesson 1: The 3 AI Horizons Leaders Should Explore | Daphne Koller

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January 23, 2026

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The term “AI” is a catch-all that spans everything from large language models (LLMs) designed to generate text to machine learning aimed at modeling and optimizing real-world outcomes. Not only can the variety be staggering, but the media buzz can make it hard to parse which tools are relevant to which types of work. Fortunately, AI experts like insitro CEO Daphne Koller have been working with this technology for decades and have learned to tune into frequencies that can help you cut through the noise.

In this video lesson, Koller pinpoints when different types of AI can prove most fruitful, and what that looks like in practice.

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About Daphne Koller:

Daphne Koller is the founder and CEO of insitro, where machine learning is applied to drug discovery and development. She also co-founded the digital learning platforms Coursera and Engageli. Koller spent 18 years as a professor of computer science at Stanford University, earning the Stanford Medal for Excellence in Fostering Undergraduate Research, and now serves as an adjunct faculty member. She was previously chief computing officer at Calico.

She was named a MacArthur Fellow in 2004. She's also been inducted into the National Academy of Engineering, the American Academy of Arts and Sciences, the International Society of Computational Biology, and the National Academy of Sciences. She has authored more than 300 peer-reviewed publications in journals including Science and Cell and was named one of TIME’s 100 most influential people in AI in 2024.

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Lesson 1: The 3 AI Horizons Leaders Should Explore | Daphne Koller · Big Think · Sentinel