Football is Now 'More Dangerous than Ever,' Says Pro Football Hall of Famer Fran Tarkenton

Fran Tarkenton, Founder and CEO of Tarkenton and Pro Football Hall of Famer, discusses his legendary football career and transition into entrepreneurial endeavors.

Early diagnosis

Chris Nowinski used to be a college football player and a WWE wrestler. Now he’s a scientist and patient advocate studying one of the biggest problems he and his friends have faced: concussion damage.

Nowinski says he felt pressure to play football “because I was tall and strong in high school — and I did not have any idea of what I was getting into.”

After retiring from wrestling due to concussion symptoms in 2003, Nowinski began researching head trauma in sports. He’s had two former teammates die with chronic traumatic encephalopathy (CTE), a serious condition where repeated blows to the head can cause brain damage, leading to symptoms like memory loss, mood swings and trouble moving.

In 2007, Nowinski started the Concussion Legacy Foundation, which supports veterans and athletes by promoting CTE scientific research and advocating for policy changes to prevent it. To study the condition, Nowinski and his foundation partnered with scientists at Boston University’s CTE Center led by Michael Alosco and Thor Stein to recruit people with suspected CTE to give blood and agree to donate their brains for research after they die.

Normally, CTE is only diagnosed after death. It’s common in American football players, who suffer repeated blows to the head from tackles and hard landings on the field, but can also be found in people who played a wide range of amateur sports as kids. CTE made headlines in July when Shane Tamura, who believed he had the condition, went to the NFL’s office building in Manhattan and shot four people before killing himself. After an autopsy, the New York City Medical Examiner’s office later confirmed that Tamura did have early stage CTE.

Diagnosing CTE in living people will be immensely important for patients and families, Nowinski says. “This is a much larger disease than anybody realizes, and once we can prove that, hopefully that will generate more interest in developing disease-modifying treatments.”

CTE, like Alzheimer’s disease, is associated with a buildup of tau protein in the brain. A blood test measuring the ratios of certain tau proteins can help diagnose Alzheimer’s disease. Nowinski and CLF are partnering with Boston University researchers Alosco and Stein to create a similar blood test for CTE.

Last year, the first patient in their study passed away. The man, Chip Collins, played tackle football for eight years and had an advanced form of CTE. Alosco, Stein and their colleagues will now be able to compare the damage in Collins’ brain to proteins they found in blood he donated during his life to begin validating the study’s diagnostic approach.

Meanwhile, a paper published in Science last month suggested that CTE is not just caused by repeated blows to the head, but also DNA damage and immune system responses similar to that of patients with Alzheimer’s disease. If confirmed, this could lead to new research for better therapies.

Though there are currently no treatments for CTE, just having a diagnosis could change how patients and loved ones deal with some of the more negative symptoms, like aggression and addiction, Nowinski says.

But his ultimate goal is to prevent the condition from happening at all. Kids and parents need to understand what’s at stake when they sign up for a youth team, he says. “This is the only major brain disease that is entirely optional.”

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