Coronavirus, Long term immunity more likely
July 20, 2020
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23:39Now PlayingCoronavirus, Long term immunity more likely
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as posted by the channelSARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls
Memory T cells induced by infection
Future susceptibility and clinical severity
Patients recovered from in COVID-19
T cells from recovered patients recognised multiple regions of the SARS-CoV-2
Patients recovered from SARS (SRS-CoV-1)
SARS-recovered patients (n=23) still possess long-lasting memory T cells reactive to SARS
17 years after the 2003 outbreak
Robust cross-reactivity to SARS-CoV-2 NP, (structural nucleocapsid protein)
Surprisingly
Frequently detected SARS-CoV-2 specific T cells in individuals with no history of SARS,
COVID-19 or contact with SARS/COVID-19 patients (n=37)
In these people the T cells were active against a different part of the virus
Epitope low homology to “common cold” human coronaviruses
Infection with betacoronaviruses induces multispecific and long-lasting T cell immunity to the structural protein NP
Cows, dogs, bats, rodents
Understanding pre-existing T cell immunity in the general population is of paramount importance for the management of the current COVID-19 pandemic
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