New US vaccine and a missing mutant
March 1, 2021
153,416
6,873
2,956
6.41%
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Dr John Campbell Episodes Around March 1, 2021
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24:37Now PlayingNew US vaccine and a missing mutant
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as posted by the channelUK
Cases, + 61,045
Down 21.2%
Hospital admissions, + 8,460
Down 22.1%
Deaths, + 2,270
Down 33.5%
Vaccine, first dose, 20,089,551
Second dose, 796,132
Pfizer in over 80s
N = 11,860 cases in the UK
Infections continue to decrease for four weeks after vaccination and then plateau
Lower rate of admission amongst vaccinated, at least 14 days after a single dose
Vaccinated individuals who do become symptomatic, protection against death.
Pfizer in over 70s
In context
SIREN (Sarscov2 Immunity and REinfection EvaluatioN), protection against infection, after a single dose of
Pfizer, 72%
Israel that suggested 75% protection against all infections
85% against symptomatic infection after a single dose of Pfizer
P1 variant
Six found in the UK in February
Unidentified person, infected with P1 variant, took a test 12th or 13th February
Should be self-isolating for 10 days
May or may not have flown into UK
Hotel quarantine rule started 15th February
United States
Trends
Hospitalizations
Vaccinations
One or more doses, 49,772,180 (15%)
Two doses, 24,779,920 (7.5%)
Ad26.COV2.S
Only single dose vaccine in use
Centers for Disease Control and Prevention, approves 3rd vaccine for over 18s
Food and Drug Administration, Saturday, emergency use
Start shipping doses, today
3.9 million doses this week
20 million doses by the end of March
Storage / transport
Up to two years frozen at –4° F (–20° C)
Up to three months refrigerated at 36–46° F (2–8° C).
Phase 3, n = 45,000
US agreed to pay Johnson & Johnson $1 billion for 100 million doses if approved
EU has ordered 200 million doses
COVAX, 500 million doses
Hoped for production, 1 billion doses in 2021
November 16, announced 2 dose Phase 3 trial
February, started trial for pregnant women
Janssen
US efficacy data
85% effective at protecting against severe cases
72% effective in preventing moderate illness
100% effective in preventing hospitalization and death after one month
Three vaccines, tested at different times, different variants, different levels of transmission
Seven deaths in the trial, all in placebo group
Saad Omer, Yale Institute of Global Health
the more severe the outcome, the more similar the efficacy
Chile
Outbreak in elderly care facility
40 tested positive
No serious illness
Three weeks after Sinovac
HTTPS://WWW.NYTIMES.COM/INTERACTIVE/2020/SCIENCE/CORONAVIRUS-VACCINE-TRACKER.HTML#SINOVAC
CoronaVac
Efficacy, 50 - 90%
2 doses, 2 weeks apart, IM, Refrigerated, Inactivated
Yet to publish
Indonesia, 11th January
Turkey, 13th January
Brazil, 17th January
Billion doses per year
India
People above 60
Over 45 with certain medical conditions
Modi accepts vaccine
Czech Republic
World’s worst surge in Covid-19 infections
Stricter enforced measures
Belgium
Government to reset vaccination programme
People over 55 could be given Oxford/AstraZeneca
Scotland, overall 81% reduction in hospital admissions
(Belgium, Germany, France, Poland, Italy)
Hospital admissions, up 44% on last week
Vaccinated, 7% (UK 31%)
EU’s 27 member states, 7.26%.
European Commission
Propose EU-wide digital Covid-19 vaccination passport
Allow Europeans to travel more freely over summer
digital green pass
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