UK variant increases mortality

Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study

54 906 matched pairs of participants

Tested positive, between 1 October 2020 and 29 January 2021

Followed-up until 12 February 2021

Death within 28 days of the first positive SARS-CoV-2 test result.

Mortality hazard ratio associated with infection with VOC-202012/1 compared with old variant, 1.64

Represents an increase in deaths from 2.5 to 4.1 per 1000 detected cases

Phase 3, 15,000 (UK) 30,000 (US and Mexico)

Reporting in April

2 doses

Intramuscular

Efficacy, 89.3% (UK data)

Much lower in SA

Developing a new version to combat SA variant

Protein based

US government support, $1.6 billion

Producing 2 billion doses per year in India

Efficacy, original strain, 96%, against mild, moderate and severe disease

Efficacy, B.1.1.7, 86%, against mild, moderate and severe disease

Efficacy, B.1.351 55%, against mild, moderate and severe disease (in non-HIV)

100% percent effective against severe disease, including against the variants

All severe cases were in the placebo groups in UK and SA

Gregory Glenn, Novavax

Our take on this is this is a very good result. It is important to prevent severe disease; it would be ideal to prevent all disease

US

Mr. Biden

All adults to be eligible for vaccination by 1st May

Small scale 4th July 1776

independence from this virus

A lot can happen. Conditions can change. The scientists have made clear that things may get worse again as new variants of the virus spread.

Find a vaccination website

(Web sites and phone lines a bottle neck?)

Dentists, veterinarians

Double the number of pharmacies participating

Double the number of federally run mass vaccination centers

Maintaining the current pace of 2 million a day

Currently, 2,233,006 per day

Mr. Trump

that beautiful shot

U.S. Olympic and Paralympic Committee

China

Offers vaccines to all Olympic competitors

July 23

Tokyo and Beijing Games

Sinovac and Sinopharm, pledged half-billion to 45 countries

Immunizing people aged 18-59

Canada

Hopes to have vaccinated adults by end of September

Kenya

Extends nationwide Covid curfew for 60 days

Cases, 111,185

Deaths, 1,899

Positive test rate, 13%

January it was 2%

Italy

Cases, + 25,673

Deaths, + 373 = 101,184

Localised surges in new cases

Lombardy, Lazio, complete lockdown from Monday

High-risk red-zones, if they have over 250 weekly cases per 100,000

Oxford AZ suspension

Italy, Romania, Thailand

Denmark, Norway and Iceland

Austria, Estonia, Latvia, Lithuania, Luxemburg (specific batch)

Germany

Health Minister Jens Spahn

No evidence of an increase in blood clots with AZ

I regret that ... some countries in the European Union have suspended vaccination with AstraZeneca

From what we know so far, the benefit ... is far greater than the risk

France and UK

EMA

Blood clots, no higher than that seen in the general population

It is not yet clear whether there is a causal association between vaccination and the reports of immune thrombocytopenia

World Health Organization

AstraZeneca, excellent vaccine, as are the other vaccines that are being used

Safe

We've reviewed the data on deaths. There has been no death, to date, proven to have be caused by vaccination

UK

41 reports of possible anaphylaxis from 5 million AZ vaccinations

Global vaccines