Aspirate to vaccinate!

Do we need to change vaccination protocols?

Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada

Thrombocytopenia has been consistently reported following the administration of adenoviral gene transfer vectors

Adenovirus-induced thrombocytopenia is a potentially serious complication of gene therapy protocols using this type of vector.

Understanding its mechanism may help the development of measures to prevent this adverse event.

In this report, we have studied platelet-adenovirus interactions in vitro and in vivo after intravenous administration of adenovirus to mice.

We show that adenovirus induces platelet activation and promotes the formation of platelet-leukocyte aggregates both in vitro and in vivo.

Thrombocytopenia occurs between 5 and 24 hours following intravenous administration of adenovirus to mice

Adenovirus activates platelets and induces rapid exposure of P-selectin

Adenovirus activates endothelial cells

Incorrect injection technique

Vaccine technique can be a rare cause of clots

State Serum Institute of Denmark, now recommends injection aspiration before injecting vaccine

There is suspicion as to whether accidental injection of the vaccine into a blood vessel could play a role

Intravascular administration may lead to a systemic inflammatory reaction leading to blood clots

Danish nursing council

Covid-19 vaccines should be given with aspiration before injection

Aspiration is recommended for all approved covid-19 vaccines

Consistent with the Danish Health and Medicines Authority's guidelines

Vaccination personnel should ensure that they are injected correctly into a muscle and not into the bloodstream

Possible connection between the AstraZeneca vaccine and rare but serious side effects with blood clots and bleeding

And the link to the updated instructions from the Danish Serum Institute

Google Translate:

Danish Nurse association

Google Translate:

When vaccinating, it is important to make sure that the vaccine does not go directly into the bloodstream.

UK and WHO guidelines

Vaccines should not be given intravenously.

It is not necessary to aspirate the syringe after the needle is introduced into the muscle (WHO, 2004; Plotkin and Orenstein, 2004).

Plotkin SA and Orenstein WA (eds) (2008) Vaccines, 5th edition. Philadelphia: WB Saunders Company.

World Health Organization (2004) Immunization in practice: a guide for health workers. WHO.

Tim Spector

Who are these guys?

Vitamin D