Informed Consent for 4th dose
April 9, 2022
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Dr John Campbell Episodes Around April 9, 2022
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18:52Now PlayingInformed Consent for 4th dose
YouTube Description
as posted by the channelProtection by a Fourth Dose of BNT162b2 against Omicron in Israel
January 2, 2022, Israel, fourth dose of BNT162b2 to over 60s
Effect on infection and severe coronavirus disease
METHODS
Israeli Ministry of Health database
1,252,331 over 60s eligible for the fourth dose
Omicron predominant, (January 10 through March 2, 2022)
Confirmed infection and severe Covid-19
Starting at 8 days after receipt of a fourth dose, (four-dose group)
Compared with (three-dose group)
Received a fourth dose 3 to 7 days earlier (internal control group)
RESULTS
Number of cases of severe Covid-19 per 100,000 person-days
Four dose group, 1.5
Three dose group, 3.9
Internal control group, 4.2
Adjusted rate of severe Covid-19
January 10, 2022, to March 2, 2022
In the fourth week after receipt of the fourth dose
Four dose group, lower than that in the three-dose group by a factor of 3.5
Four dose group, lower than that in the internal control group by a factor of 2.3
Protection against severe illness did not wane during the 6 weeks after receipt of the fourth dose.
The number of cases of confirmed infection per 100,000 person-days (unadjusted rate)
Four dose group, 177
Three dose group, 361
Internal control group, 388
Confirmed infection in the fourth week
January 10, 2022, to March 2, 2022
Four dose group, lower than that in the three-dose group by a factor of 2.0
Four dose group, lower than that in the internal control group by a factor of 1.8
However, this protection waned in later weeks.
CONCLUSIONS
Rates of confirmed SARS-CoV-2 infection and severe Covid-19 were lower after a fourth dose of BNT162b2 vaccine than after only three doses.
Protection against confirmed infection appeared short-lived, whereas protection against severe illness did not wane during the study period.
We excluded the following persons from the analysis
those who had had a confirmed SARS-CoV-2 infection before the beginning of the study,
So this tells us nothing about the effect of natural immunity
Please can we have data on vaccine induced immunity
versus natural infection induced immunity
AND
Efficacy of fourth dose versus two or three dose hybrid immunity
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