Vitamin D and diabetes
February 7, 2023
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15:18Now PlayingVitamin D and diabetes
YouTube Description
as posted by the channelVitamin D and Risk for Type 2 Diabetes in People With Prediabetes, (7th Feb 2023)
HTTPS://WWW.ACPJOURNALS.ORG/DOI/10.7326/P22-0031?UTM_SOURCE=CMPNR&UTM_CAMPAIGN=LFA_230207_A&UTM_CONTENT=3&CMP=1&UTM_MEDIUM=EMAIL
Vitamin D has many functions in the body,
including a role in insulin secretion and glucose metabolism.
Observational studies,
association between low level of vitamin D in the blood,
and high risk for developing diabetes.
So, does giving vitamin D to people who were at high risk for diabetes reduce the risk?
Authors searched 3 databases,
through 9 December 2022
Compare the use of vitamin D versus placebo for diabetes prevention,
in adults with prediabetes.
Meta analysis and reanalysis of pooled data
Trials were at low risk for bias
Results
Over 3 years of follow-up
Vitamin D group
New-onset diabetes occurred in 22.7%
Placebo group
New-onset diabetes occurred in 25%
Translates to being 15% reduction
Number needed to treat to prevent one case of diabetes
30 adults with prediabetes to prevent 1 person from developing diabetes.
Risk reduction by blood levels
At least 125 nmol/L (≥50 ng/mL) group
50 to 74 nmol/L (20 to 29 ng/mL) group
Cholecalciferol reduced risk for diabetes by 76%
(hazard ratio, 0.24)
3-year absolute risk reduction of 18.1%
Vitamin D increased the likelihood of regression to normal glucose regulation by 30%
Doses used
20,000 units of cholecalciferol (vitamin D3) weekly
4000 units of cholecalciferol daily
0.75 micrograms of eldecalcitol, (synthetic analogue of vitamin D)
Adverse events
Rare, study could not draw any definite conclusions about safety
kidney stones
hypercalcemia
hypercalciuria
Implications
In adults with prediabetes,
vitamin D was effective in lowering the risk for developing diabetes.
By the Numbers: Diabetes in America
Total Diabetes
From 2001 to 2020,
diabetes prevalence significantly increased among over 18s
37.3 million people have diabetes
(11.3% of the US population).
28.7 million people have been diagnosed with diabetes.
8.5 million people who have diabetes have not been diagnosed
(do not know they have it)
Total Prediabetes
96 million US adults have prediabetes.
Cost of Diabetes (2017)
$327 billion,
$237 billion direct medical costs
$90 billion in lost productivity
Excess medical costs, $9,601 per person
UK prevalence
4.8 million (7%)
3.9 million diagnosed
1 million undiagnosed
5.3 million by 2025
People with type 2 diabetes
50% more likely to die prematurely
Two-and-a-half times more likely to. Develop heart failure
Twice more likely to have a heart attack
Obesity, sugars, carbohydrates, processed foods, exercise, vitamin D
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