Circulating spike protein after vaccination, Boston research
April 17, 2023
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18:31Now PlayingCirculating spike protein after vaccination, Boston research
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Circulating Spike Protein Detected in Post-COVID-19 mRNA Vaccine Myocarditis
Background
Cases of adolescents and young adults developing myocarditis,
after vaccination with (SARS-CoV-2)-targeted mRNA vaccines,
reported globally,
underlying immunoprofiles of these individuals have not been described in detail.
Methods
January 2021 through February 2022
Prospectively collected blood,
from 16 patients, (12 to 21 years)
13 male
12 after 2nd dose
Onset 4 days post vaccination
hospitalized at Massachusetts General for Children,
or Boston Children's Hospital,
for myocarditis
Presentation
Chest pain
Elevated cardiac troponin T,
after SARS-CoV-2 vaccination.
We performed
Extensive antibody profiling,
including tests for SARS-CoV-2-specific humoral responses,
and assessment for autoantibodies,
or antibodies against the human-relevant virome,
SARS-CoV-2-specific T-cell analysis,
and cytokine,
and SARS-CoV-2 antigen profiling.
Comparator group
45 healthy, asymptomatic, age-matched vaccinated control subjects.
Results, things that were the same
(Between the myocarditis group and non myocarditis group)
Antibody profiling IgG and IgM the same
T-cell responses the same
(were essentially indistinguishable)
Results, things that were different
(Between the myocarditis group and non myocarditis group)
In the myocarditis group
Modest increase in cytokine production
(reminiscent of the profile seen in MIS-C)
Total leukocytes, specifically neutrophils, significantly increased
Markedly elevated levels of full-length spike protein,
(33.9±22.4 pg/mL),
unbound by antibodies,
were detected in the plasma of individuals with postvaccine myocarditis,
No free spike was detected in asymptomatic vaccinated control subjects
(unpaired t test; P less than 0.0001).
Why spike protein persisted?
In postvaccine myocarditis,
the spike protein appears to evade antibody recognition,
because the anti-spike antibodies that are generated are produced in adequate quantities with normal functional and neutralization capacity.
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