Dr John Campbell
@campbellteaching·3.3M subscribers·3.1K videos
Ebola and other deaths
Posted
May 29, 2026
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71,601
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May 29, 2026
71,601
6,894
1,704
12.01%
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17:34Now PlayingDeadliest Ebola outbreak in history
West African Ebola epidemic of 2014–2016
Guinea, Liberia, Sierra Leone.
Cases: 28,600 reported
Deaths: More than 11,300
Outbreak began in late 2013 in Guinea,
spread across borders into densely populated urban areas.
Second largest outbreak
Democratic Republic of the Congo, 2018–2020
Cases: 3,400
Deaths: 2,300
Global Malaria deaths, 2024
Cases: 282 million
Deaths: 610, 000
2024 Malaria deaths in Africa
Cases: 265 million
Deaths: 579, 000
Children under 5
Accounted for 75% of all malaria deaths in Africa.
Other causes of death in Africa
Lower respiratory infections, 774, 000
Diarrhoeal diseases, 496,000
HIV/AIDS, 435,000
Ischaemic heart disease, 429,000
Stroke, 426,000
TB, 378,000
Road injuries, 297,000
Hungry kids need food
Nairobi, 23 April 2025 (UNICEF data)
Acutely malnourished in 2025
13 million children
Severe acute malnutrition (SAM)
4 million children
Stunting (Childhood chronic undernutrition)
62 million children under 5 in sub-Saharan Africa are stunted.
New vaccines for Bundibugyo ebolavirus
ChAdOx1 Bundibugyo vaccine (Oxford / Serum Institute)
Uses the chimpanzee adenovirus (ChAdOx1) platform
Similar technology was used in the Oxford AZ COVID-19 vaccine
Potentially be ready for early efficacy assessment in 2–3 months
How the ChAdOx system works
Genes for the antigen are inserted into a viral vector
Injection(im)
Biodistribution
Cell entry
Delivers DNA instructions into the cell
Antigen production
Cell manufactures the viral protein:
Both cause human cells to manufacture a viral antigen
COVID vaccine → spike protein
Ebola vaccine → Ebola glycoprotein
For the SARS-CoV-2, spike protein, immunologically important antigen, is believed to be associated with cells surfaces rather than freely circulating.
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