Dr John Campbell
Dr John Campbell
@campbellteaching·3.3M subscribers·3.1K videos

Ebola and other deaths

Posted

May 29, 2026

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Deadliest Ebola outbreak in history

West African Ebola epidemic of 2014–2016

Guinea, Liberia, Sierra Leone.

Cases: 28,600 reported

Deaths: More than 11,300

Outbreak began in late 2013 in Guinea,

spread across borders into densely populated urban areas.

Second largest outbreak

Democratic Republic of the Congo, 2018–2020

Cases: 3,400

Deaths: 2,300

Global Malaria deaths, 2024

Cases: 282 million

Deaths: 610, 000

2024 Malaria deaths in Africa

Cases: 265 million

Deaths: 579, 000

Children under 5

Accounted for 75% of all malaria deaths in Africa.

Other causes of death in Africa

Lower respiratory infections, 774, 000

Diarrhoeal diseases, 496,000

HIV/AIDS, 435,000

Ischaemic heart disease, 429,000

Stroke, 426,000

TB, 378,000

Road injuries, 297,000

Hungry kids need food

Nairobi, 23 April 2025 (UNICEF data)

Acutely malnourished in 2025

13 million children

Severe acute malnutrition (SAM)

4 million children

Stunting (Childhood chronic undernutrition)

62 million children under 5 in sub-Saharan Africa are stunted.

New vaccines for Bundibugyo ebolavirus

ChAdOx1 Bundibugyo vaccine (Oxford / Serum Institute)

Uses the chimpanzee adenovirus (ChAdOx1) platform

Similar technology was used in the Oxford AZ COVID-19 vaccine

Potentially be ready for early efficacy assessment in 2–3 months

How the ChAdOx system works

Genes for the antigen are inserted into a viral vector

Injection(im)

Biodistribution

Cell entry

Delivers DNA instructions into the cell

Antigen production

Cell manufactures the viral protein:

Both cause human cells to manufacture a viral antigen

COVID vaccine → spike protein

Ebola vaccine → Ebola glycoprotein

For the SARS-CoV-2, spike protein, immunologically important antigen, is believed to be associated with cells surfaces rather than freely circulating.

Guests & Subjects Covered

Deadliest EbolaWest African EbolaDeaths MoreDemocratic RepublicGlobal MalariaAfrica CasesAfrica OtherAfrica Lower

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Ebola and other deaths · Dr John Campbell · Sentinel