Dr John Kruse
@drjohnkruse·16.8K subscribers·484 videos
Vyvanse - Why is it So Popular?
Posted
December 29, 2024
Views
21,475
Likes
437
Comments
124
Engagement
2.61%
December 29, 2024
21,475
437
124
2.61%
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Vyvanse doesn't work at all! That's because it's an inactive prodrug that an enzyme on red blood cells splits into its two parts - the amino acid lysine and the stimulant dextroamphetamine. Dextroamphetamine is a powerful reuptake inhibitor at dopamine and norepinephrine receptors in the brain, as well as forcing synaptic vesicles to release extra big doses of these neurochemicals.
The red blood cell action means that Vyvanse has a delayed onset, and is less perturbed by acidity, or intestinal absorption variation compared to other stimulants. The commonest adjective I've heard people use to describe Vyvanse is "smooth". For most people Vyvanse starts working an hour or two after consumption, and lasts for 12-14 hours.
In addition to being a well designed product, Vyvanse was heavily marketed. Both factors contributed to it being the single most widely prescribed stimulant in the US, as well as leading to over $10 billion in worldwide sales (2022). Vyvanse became a generic medication in the US in September 2023.
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Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions.
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