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The Agentic Entrepreneur: How the next wave of AI is changing the startup playbook

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October 4, 2025

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This week on the GeekWire PodcastHow artificial intelligence is changing the way companies are created, built, and operated. We're on location at Pioneer Square Labs () in Seattle with investor and entrepreneur T.A. McCann () , a managing director at the startup studio and venture capital firm.

He explains how AI agents are automating complex functions, letting small teams do the work that once required large groups of people. As AI makes product development easier, he says, the key strategic moat for many startups is now shifting to distribution and data.

Other topics include:

The wearable AI recorder that captures everything he says throughout the day.

The rise of the "one-person billion-dollar company" powered by a suite of specialized AI agents.

How AI-generated personas are replacing human focus groups for market research.

The future of "agent-to-agent" conversations, where different AI systems negotiate with each other on behalf of their companies.

With GeekWire co-founder Todd Bishop; Edited by Curt Milton.

See omnystudio.com/listener () for privacy information.

Guests & Subjects Covered

The Agentic EntrepreneurGeekWire Podcast HowPioneer Square LabsTA McCannAs AIHow AI-generatedWith GeekWireTodd Bishop Edited

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The Agentic Entrepreneur: How the next wave of AI is changing the startup playbook · Geekwire · Sentinel