Low vitamin D and increased deaths
June 18, 2026
22 min
Full
248 of 364
June 18, 2026
Low vitamin D and increased deaths
0:00 / 22:07
Excerpt playback isn’t available for this episode — use the full-episode link.
Search the Record
Moment search isn’t open for this episode yet
When it opens, you’ll be able to type any phrase and jump straight to the second it was said.
Dr John Campbell Episodes Around June 18, 2026
Episode 248 of 364 — walk the feed in the order it was published.
22:07This episodeLow vitamin D and increased deaths
Summary
Lower levels of vitamin D, higher rates of death
Association of Serum 25-Hydroxyvitamin D Concentrations With All-Cause and Cause-Specific Mortality Among Adult Patients With Existing Cardiovascular Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496747/
Observational study, non-interventional
Background
Vitamin D, lower levels, common in patients with cardiovascular disease (CVD)
Study of patients with existing CVD
Prospectively examine the associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations with,
All-cause mortality and,
cause-specific mortality
Methods
N = 37,079 patients with CVD from the UK
Biobank study
From a prospective cohort of half a million, aged 40–69 years
https://www.ukbiobank.ac.uk
CVD
Coronary heart disease
Atrial fibrillation
Heart failure
Stroke
Results
Among 37,079 patients with CVD at baseline, 57.5% were vitamin D deficient
Deficient, 25[OH]D less than 50 nmol/L (less than 20ng/ml)
Median follow-up of 11.7 years
Deaths that occurred = 6,319 total
2,161 deaths from CVD
2,230 deaths from cancer
623 deaths from respiratory disease
1,305 other-cause deaths
Non-linear inverse associations
For all-cause mortality
Cancer mortality
Respiratory disease mortality
Other-cause mortality
That is deaths went up as vitamin D levels went down
(P-non-linearity less than 0.01)
Approximately linear inverse associations for CVD
That is deaths went up as vitamin D levels went down
(P-non-linearity = 0.074)
Among CVD patients with vitamin D deficiency
For every 10 nmol/L increment in serum 25(OH)D concentrations,
There was an associated 12% reduced risk for all-cause mortality
There was an associated 9% reduced risk for CVD mortality.
In patients with vitamin D deficiency
Per 10 nmol/L increase in serum 25(OH)D levels,
was associated with a lower risk of mortality from (aHR]; 95% CI)
All-cause 0.88
CVD 0.91
Cancer 0.90
Respiratory diseases 0.81
Other causes 0.81
Multivariable Cox regression models
Age, sex, alcohol, BMI, GFR, education, ethnicity, household income, smoking status, healthy diet score, diabetes (and meds), HbA1c, duration of CVD, blood pressure (and meds), lipid profile (and meds), triglycerides, cholesterol