Lab leaks

Accidentally on purpose

https://dictionary.cambridge.org/dictionary/english/accidentally-on-purpose

WEF prepares for Disease X

https://www.weforum.org/events/world-economic-forum-annual-meeting-2024/sessions/preparing-for-a-disease-x/?utm_source=substack&utm_medium=email

Laboratory-acquired infections and pathogen escapes worldwide between 2000 and 2021

https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00319-1/fulltext

Laboratory-acquired infections (LAIs),

and accidental pathogen escape from laboratory settings (APELS),

are major concerns for the community.

A risk-based approach for pathogen research management,

within a standard biosafety management framework is recommended,

but is challenging.

due to reasons such as inconsistency,

in risk tolerance and perception.

Here, we performed a scoping review,

using publicly available, peer-reviewed journal and media reports,

of LAIs and instances of APELS between 2000 and 2021.

Laboratory-acquired infections (LAIs)

309 individuals, 94 reports for 51 pathogens.

Eight fatalities

2·6% of all LAIs

Neisseria meningitidis (n=3, 37·5%)

Yersinia pestis (n=2, 25%)

Salmonella enterica serotype Typhimurium (n=1, 12·5%)

Ebola virus (n=1, 12·5%)

Bovine spongiform encephalopathy (n=1, 12·5%)

Accidental pathogen escape from laboratory settings (APELS)

16 APELS were reported

Bacillus anthracis (anthrax)

SARS-CoV

Poliovirus

Brucella spp (brucellosis zoonosis)

Foot and mouth disease virus

Influenza virus H5N1

Examples

the discovery of historical variola virus ampoules in cold storage during a move of laboratories at the National Institutes of Health campus in Bethesda, MD, USA in July, 2014

the shipment of live anthrax cultures from US Department of Defense laboratories following incomplete inactivation

Lethal Infection of Human ACE2-Transgenic Mice Caused by SARS-CoV-2- related Pangolin Coronavirus GX_P2V(short_3UTR)

https://www.biorxiv.org/content/10.1101/2024.01.03.574008v1.full.pdf

SARS-CoV-2-related pangolin coronavirus GX_P2V can cause 100% mortality in human ACE2-transgenic mice,

potentially attributable to late-stage brain infection.

This underscores a spillover risk of GX_P2V into humans

https://www.biblegateway.com