Injections versus infections, Pandemic update

UK

Cases, + 35,475 (rolling 7 day average to 24 December) = 2,288,345

Hospitalised, + 2,143 = 21,286 (1,529)

Previous peak, 12 April = 21,683

Vaccinated, 616,933

Injections versus infections

Deaths, + 316 = 70,752

Deaths, + 3,062 = 79,349 (COVID mentioned as one of the causes)

Delays

14th December

Cases, + 20,264

27th December

Hospital admissions, 2,143

10.5%

London Ambulance Service

Emergency calls, 26 December = 7,918

Same as peak of first wave

Up 2,500 on 26 December 2019

NHS England

Entire health service, remain on highest alert, end of March

Mobilise all of the available surge capacity over the coming weeks

Surgical patients to local private facilities

Discharge as many inpatients as possible

Prepare for Nightingale openings

London’s Royal Free Hospital

Cancelled all non-emergency surgery until mid-February

Restricted staff holidays

Sir Jeremy Farrar, Scientific Advisory Group for Emergencies

Reopening schools in January very finely balanced

It is going be a trade-off between one or other

You cannot have everything.

You cannot have the whole of society opening, and schools opening and further education and universities,

and keep R below one with this variant

A British national disgrace

Verbier

UK to Switzerland flights stopped 20 December

Swiss authorities, 21 December

Arrivals from UK since 14 December, need to self-isolate for 10 days

Swiss authorities tracked down 420

Half missing, geflohen, some later reporting to hotels in France

Some rang hotels later to try to get money back

2020 12 Variant

Denmark, Germany, Singapore, France, Japan, Spain, Australia, Lebanon, Sweden, Netherlands, Italy, Canada

United States

CDC trends (Saturday, 28th December)

Official US hospitalizations

Last reliable data, 21st November

Cases, + 152,461 = 18,907,656

Up 7.1% over past 7 days

Hospitalizations, 118,720 (22,447) (7,878)

Deaths, 324,796

Storm Chaser, Phase 3

Double blind

Placebo controlled

AZD7442 monoclonal antibodies

Two mAbs to the SARS-CoV-2 S protein RBD

Six to 12 months

Fc Amino acid substitutions

Extend their half-lives

Decrease Fc effector function to decrease the potential risk of antibody-dependent enhancement of disease

Started 2nd December

N = 1,125 people globally

Healthcare workers

Students in shared accommodation

Recently exposed patients

Long-term care

Military

Factory workers

Timetable

Reports, 4th January

Approval, March or April

UCLH virologist Dr Catherine Houlihan

We know that this antibody combination can neutralise the virus,

so we hope to find that giving this treatment via injection can lead to immediate protection against the development of Covid-19 in people who have been exposed

Provent trial