Rule changes for fully vaccinated

REACT 1 study, Imperial, 13th May

N = 127,000, home PCR swab tests

Positive, 115

15th April to 3rd May

Prevalence, 0.1% of the population or 1 in 1,000

(March 30th 0.2% or 1 in 500)

R = 0.9

Since January, link between the rate of infections, hospitalisations and deaths, de-coupled

B.1.1.7, 24 samples = 92.3%

B.1.617.2, 2 samples = 7.7%

Both from London, no travel history

UK, India variant

Public Health England, cases = 1,313

5th May, n = 520

Department of Health and Social Care

Ministers cannot rule out re-imposing economic and social restrictions at a local or regional level if evidence suggests they are necessary to contain or suppress a variant which escapes the vaccine

Regional restrictions possible

Surge testing in 15 areas across England

Cluster areas, increased genome sequencing

Bringing forward second vaccine for people who are eligible

Prime Minister

It is a variant of concern, we are anxious about it

US

Deaths, 580,837

One dose, 46.6%

Fully vaccinated, 35.8%

CDC, 13th May

If you’ve been fully vaccinated:

resume activities that you did prior to the pandemic

resume activities without wearing a mask or staying 6 feet apart,

except where required locally

Domestic travel, do not need tested before or after travel or self-quarantine after

do NOT need to get tested before leaving the United States unless your destination requires it.

still need a negative test or evidence of recovery before boarding an international flight to the United States

should still get tested 3-5 days after international travel

do NOT need to self-quarantine after arriving in the United States.

If you’ve been around someone who has COVID-19, you do not need to stay away from others or get tested unless you have symptoms

Except, correctional, detention facility or a homeless shelter

For now, if you’ve been fully vaccinated:

follow guidance at your workplace and local businesses

Masks on planes, buses, trains, domestic and international

International arrivals, test within 3 days

Test and stay at home is symptomatic

Weaken immune system, talk to their healthcare provider

Association Between Vaccination With BNT162b2 and Incidence of Symptomatic and Asymptomatic SARS-CoV-2 Infections Among Health Care Workers (JAMA, 6th May)

Single-center, retrospective cohort study, Tel Aviv

Data were collected on symptomatic and asymptomatic SARS-CoV-2 infections confirmed via polymerase chain reaction

December 20, 2020, to February 25, 2021

N = 6,710 health care workers

Symptomatic SARS-CoV-2 infection

Incidence rate fully vaccinated = 4.7 per 100,000 days

Incidence rate unvaccinated = 149.8 per 100,000 days

97% protection

Asymptomatic SARS-CoV-2 infection

Incidence rate fully vaccinated = 11.3 per 100,000 days

Incidence rate unvaccinated = 67 per 100,000 days

86% protection

Letter from 1,500 Doctors to the French Health Minister asking for an Emergency Use Authorisation of ivermectin

Right to care of their patients

Criteria met for risk to benefit ratio

Chemo prophylaxis is relevant to stem the pandemic

Vigibase, pharmacovigilance data, 130 countries

Past 30 years

Ivermectin, 16 deaths and 4,700 adverse effects

Doliprane, 3,695 deaths and 161,147

Minister,

March 31, 2020, National Medicines Safety Agency rejected our request for a Temporary Recommendation for Use for Ivermectin

This refusal represents for us a serious threat to public health