Professor Dave Explains
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Fischer Indole Synthesis
Posted
August 5, 2021
Views
62,373
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1,243
Comments
35
Engagement
2.05%
August 5, 2021
62,373
1,243
35
2.05%
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7:44Now PlayingWe've talked about a few heterocycles, but one important aromatic one we didn't mention is the indole. This is a component of a variety of biomolecules. So how can we make them? Nobel prize winner Emil Fischer developed the Fischer indole synthesis in 1882 to do precisely this, using aryl hydrazines and ketones. What's the mechanism? Is that a sigmatropic shift you spot in there? Yes it is! It's a fun one, check it out.
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