Fischer Indole Synthesis
August 5, 2021
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7:44Now PlayingFischer Indole Synthesis
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as posted by the channelWe've talked about a few heterocycles, but one important aromatic one we didn't mention is the indole. This is a component of a variety of biomolecules. So how can we make them? Nobel prize winner Emil Fischer developed the Fischer indole synthesis in 1882 to do precisely this, using aryl hydrazines and ketones. What's the mechanism? Is that a sigmatropic shift you spot in there? Yes it is! It's a fun one, check it out.
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