Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg
In this Huberman Lab Essentials episode, my guest is Dr. Justin Sonnenburg, PhD, a professor of microbiology and immunology at Stanford University.
December 11, 2025
39 min
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362 of 417

December 11, 2025
Essentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg
0:00 / 39:27
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Andrew Huberman Episodes Around December 11, 2025
Episode 362 of 417 — walk the feed in the order it was published.
50:00Essentials: Breathing for Mental & Physical Health & Performance | Dr. Jack Feldman
39:27This episodeEssentials: How to Build, Maintain & Repair Gut Health | Dr. Justin Sonnenburg
Summary
In this Huberman Lab Essentials episode, my guest is Dr. Justin Sonnenburg, PhD, a professor of microbiology and immunology at Stanford University.
We discuss how microbes in our gut impact our mental and physical health and how diet and the environment affect the gut microbiome. We explain how lifestyle factors such as antibiotics and Western-style diets (high fat, low fiber and rich in processed foods) can damage gut diversity and whether prebiotics or probiotics are useful tools. Throughout the episode, we highlight evidence-based dietary and lifestyle strategies for improving gut health.
Episode show notes: https://go.hubermanlab.com/VXfckJf
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Timestamps
00:00:00 Justin Sonnenburg
00:00:20 What is the Microbiome?
00:02:55 Microbiome Origin, Babies, Environmental Factors
00:04:47 Healthy Microbiome, Individuality; Industrialized vs Traditional Populations
00:07:06 Sponsor: AG1
00:08:30 “Reprogramming” the Gut Microbiome; Antibiotics, Western Diet
00:12:58 Cleanses & Fasting
00:13:55 Processed Foods & Microbiome, Artificial Sweeteners, Emulsifiers
00:17:35 Sponsor: Joovv
00:18:55 Inflammatory Western Diseases, Microbiome & Immune System
00:21:51 Fiber, Fermented Foods & Microbiome, Tool: Fermented Food Consumption
00:28:20 Sponsor: Function
00:30:00 Fiber, Depleted Microbiome, Industrialization, Sanitation
00:31:33 Antibiotics, Over-Sanitation, Disease, Hand Washing
00:33:26 Probiotics, Tool: Product Validation,
00:35:15 Prebiotics, Tool: Plant Consumption
00:37:48 Good Gut Book, Justin’s Research
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