Does Hydroxychloroquine work?
May 10, 2020
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19:31Now PlayingDoes Hydroxychloroquine work?
YouTube Description
as posted by the channelNo seems to be the simple answer.
Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19
(NEJM 7th May)
BACKGROUND
Hydroxychloroquine, widely used without robust evidence
Anti-inflammatory and antiviral effects
Food and Drug Administration, Emergency Use Authorization on March 30, 2020,
METHODS
Examined the association between hydroxychloroquine use and respiratory failure
Association between hydroxychloroquine use and intubation or death
New York–Presbyterian Hospital (NYP)–Columbia University Irving Medical Cente
1,446 consecutive patients
Tested positive for antigen
Compared outcomes, hydroxychloroquine or not
Hydroxychloroquine indicated in moderate-to-severe respiratory illness
Oxygen saturation of less than 94% on room air
RESULTS
1,376 patients followed up for 22.5 days
March 7 to April 8, 2020. Follow-up to April 25, 2020
811 (58.9%) received hydroxychloroquine
1,376 respiratory failure developed in 346 patients (25.1%)
180 patients were intubated, and 166 died without intubation
No significant association between hydroxychloroquine use and intubation or death
CONCLUSIONS
Hydroxychloroquine administration was not associated with either a greatly lowered or an increased risk of intubation or death
Findings do not support the use of hydroxychloroquine at present, outside randomized clinical trials testing its efficacy
Clinical guidance at our medical center has been updated to remove the suggestion that patients with Covid-19 be treated with hydroxychloroquine
Were Hydroxychloroquine-treated patients were more severely ill at baseline?
Adjusted for likely confounders,
Age
Race and ethnic group
Body-mass index
Diabetes
Chronic kidney disease
Chronic lung disease
Hypertension
Baseline vital signs
Oxygen therapy
Inflammatory markers
Unmeasured confounding may remain
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