Dr John Campbell
@campbellteaching·3.3M subscribers·3.1K videos
New Syndrome in Children
Posted
May 14, 2020
Views
189,059
Likes
6,543
Comments
1,861
Engagement
4.45%
May 14, 2020
189,059
6,543
1,861
4.45%
Every word spoken in this episode is indexed. Type any phrase to jump straight to the moment it was said.
Type any word or phrase that may have been spoken. Click a result to seek the player to that exact moment.
Try a name, a topic, or a quoted line
28:38Now PlayingCOVID – 19, Thursday 14th May
Paediatric Multisystem Inflammatory Syndrome
Cases in the US, Spain, Italy, France, Netherlands, but not China
Most of the children tested negative for coronavirus, but tested positive for detection of antibodies
Children, up to 6-week delay
US
Doctors are investigating cases in at least 150 children, most of them in New York
CNN survey
17 states have suspected cases
Dr Burns Boston Children’s Hospital;
‘This multisystem inflammatory syndrome is not directly caused by the virus’
‘The leading hypothesis is that it is due to the immune response of the patient’
UK
Up to 100 children affected
Some have needed intensive care while others recovered quickly
Clinical features
High fever
Rash
Red eyes
Swelling
Abdominal pain
Diarrhoea or vomiting
Confused or overly sleepy
General pain
Renal or cardiac involvement
Evidence of blood vessel inflammation;
Red eyes
Bright red tongue
Cracked lips
Early treatment to prevent organ damage
Children with the presentation appear to be responding well to intravenous immunoglobulin and/or steroids.
Hyperinflammatory shock in children during COVID-19 pandemic, The Lancet
)310941.pdf
South Thames Retrieval Service, 2 million children
10 days in mid April, 2020, 8 children
National alert
All children were previously fit and well
6 out of 8 were of Afro-Caribbean descent
5 out of 8 were boys
Clinical presentations
Unrelenting fever (38–40°C)
Variable rash
Conjunctivitis
Peripheral oedema
Generalised extremity pain
Significant gastrointestinal symptoms
All progressed to warm, vasoplegic shock
Refractory to volume resuscitation
Eventually requiring noradrenaline and milrinone for haemodynamic support
Most of the children had no significant respiratory involvement
Pleural, pericardial, and ascitic effusions, suggestive of a diffuse inflammatory process.
All children tested negative for severe acute respiratory syndrome coronavirus 2
No pathological organism was identified in seven of the children
Adenovirus and enterovirus were isolated in one child.
Inflamed coronary arteries
One death from a large cerebrovascular infarct
A new phenomenon affecting previously asymptomatic children with SARS-CoV-2 infection
Multifaceted nature of the disease
epidemic: an observational cohort stud
)31103X/fulltext
Sentinel Indexing in Progress
Metadata and chapters are available. Claim extraction for this episode is pending.
All video content is delivered via YouTube embedded players in accordance with the YouTube Terms of Service. Sentinel provides research tools that promote discovery and accountability across political media.
