Dr John Campbell
@campbellteaching·3.3M subscribers·3.1K videos
Covid causing diabetes
Posted
August 12, 2021
Views
242,865
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6,301
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August 12, 2021
242,865
6,301
2,887
3.78%
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40:49Now PlayingDiabetes morbidity, India, 77 million, China, 116 million, UK, 3.9million, US 34 million
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UK 3.9 to 4.7 million, + 700 new cases per day
US, 34.2 million
Rhino-orbital mucormycosis following COVID-19 in previously non-diabetic, immunocompetent patients
India, more than 45,000 cases of Mucormycosis
Affects nose, eyes and sometimes the brain
Usual onset, 12-18 days after recovery from Covid-19
13 of 127 patients had new onset diabetes
Average age, 36 years
Seven of 13, not given steroids or supplemental oxygen
Covid-19: Fears over sharp rise in diabetes in India
Dr Anoop Misra
Our assessment is that such patients were probably predisposed to diabetes because of obesity and family history
Severe diabetes caused by pancreatic damage, less common
Proportion of newly diagnosed diabetes in COVID-19 patients: A systematic review and meta-analysis
Meta-analysis, 8 studies, n = 3,700 patients
14.4% for newly diagnosed diabetes in hospitalized COVID-19 patients
newly diagnosed diabetes may confer a greater risk for poor prognosis
We are now seeing a classic example of a lethal intersection between a communicable and a non-communicable disease.
Physiology
Stress response associated with severe illness
Treatment with glucocorticoids
Diabetogenic effect of COVID-19 should also be considered
High degree of insulin resistance
High insulin requirements in severely or critically ill COVID-19 patients with diabetes
More diabetic ketoacidosis and hyperosmolar hyperglycaemic in COVID-19 patients with diabetes
SARS-CoV-2), attaching to ACE2 receptors in beta cells
May also injure beta cells by pro-inflammatory cytokines (e.g. interleukin-6)
Enhancing autoimmunity in genetically predisposed people
ACE2 receptors are expressed in the liver, adipose tissue and skeletal muscle
May impair responses to insulin
Exploring research: can coronavirus cause diabetes, or make it worse?
't%20produce%20enough%20insulin.
47,000 people in England, admitted to hospital for coronavirus before August 2020
Seven months after discharged
5% of people went on to develop diabetes
Hospitalised patients, 1.5 times more likely to be diagnosed with diabetes after discharge
Matched with non- hospitalised people of the same age and background
Lets find out
Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study
Follow-up of 140 days, 47,780 admissions
14,060 of readmitted (x4)
5,875 died after discharge (x8)
Also increased
Respiratory disease (P 0.001)
Diabetes (P 0.001)
Cardiovascular disease (P 0.001)
Increased rates of multiorgan dysfunction
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