Lithium for Dementia?
August 31, 2025
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19:37Now PlayingLithium for Dementia?
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Although lithium is considered to be one of the three elements created in the Big Bang, it represents less than 0.002% of the earth's crust, and unlike many other metals found in trace amounts in the human body, has long been considered inessential for animal or plant life. Lithium's very low density, and ready ability to move electrons together have made lightweight lithium batteries ideal to power many of today's portable electronic gear.
For more than a half century lithium carbonate, in doses usually in the 600-2400 mg range, has been considered the gold standard treatment for bipolar disorder, even while its market share has declined steadily for decades.
Lithium has been considered a general tonic for generations - when 7-Up was first marketed over 95 years ago it was promoted as a "lithiated lemon lime soda". Now, a compelling, complex, studies of lithium makes a strong case that low doses of lithium orotate (10 mg) may have a role in preventing and treating dementia.
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Free link to my Medium Article on Lithium and Dementia:
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References:
Lithium deficiency and the onset of Alzheimer’s disease (2025)
Risk of dementia in bipolar disorder and the interplay of lithium: a systematic review and meta-analyses (2020)
Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial (2018)
Association of Lithium in Drinking Water With the Incidence of Dementia (2017)
The history of lithium therapy (2013)
A Randomized, Double-Blind, Crossover Study of Methylphenidate and Lithium in Adults With Attention-Deficit/Hyperactivity Disorder: Preliminary Findings (2002)
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Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions.
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