Dr John Kruse
@drjohnkruse·16.8K subscribers·484 videos
Lamictal (Lamotrigine) for ADHD
Posted
February 15, 2026
Views
1,412
Likes
43
Comments
1
Engagement
3.12%
February 15, 2026
1,412
43
1
3.12%
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2:00Now PlayingLamotrigine was chosen for its anti-folate properties, turned out to be a decent antiseizure medication and was then repurposed and approved to treat bipolar disorder, particularly bipolar depressions. In the US it is the most widely prescribed mood stabilizer and #2 for seizures. This popularity arises despite not knowing how lamotrigine works in the brain, and is due largely to being much less likely than its competitors to cause problematic side effects. While lamotrigine does act as a sodium and calcium channel blocker, and has moderate serotonin-3 blocking ability, it is not clear if any of these mechanisms of action explain its benefits. While lamotrigine has been examined in individuals with both ADHD and epilepsy, and ADHD and bipolar disorder, and appears to be safe, it is not clear that lamotrigine directly lowers ADHD symptoms, or whether improvement in ADHD symptoms in these open studies came from treating the seizures or the mood disorder.
#health #mentalhealth #adhd #lamictal #lamotrigine
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