Manolis Kellis
@manoliskellis1·24.9K subscribers·255 videos
MIT CompBio Lecture 17 - Comparative Genomics (Fall 2019)
Posted
November 5, 2019
Views
2,882
Likes
38
Comments
3
Engagement
1.42%
November 5, 2019
2,882
38
3
1.42%
Every word spoken in this episode is indexed. Type any phrase to jump straight to the moment it was said.
Type any word or phrase that may have been spoken. Click a result to seek the player to that exact moment.
Try a name, a topic, or a quoted line
See what was published immediately before and after this episode.
1:22:57Now PlayingMIT Computational Biology: Genomes, Networks, Evolution, Health
Prof. Manolis Kellis
Full playlist with all videos in order is here
All slides from Fall 2019 are here
Outline for this lecture:
1. Nucleotide conservation: evolutionary constraint
- Purifying selection, neutral branch length, discovery power
- Detect constrained elements: nucleotides, windows, HMM
- Estimate fraction constrained: signal vs. background
2. Evolutionary signatures: focus on pattern of change
- Different functions == Characteristic patterns of evolution
3. Signatures of protein-coding genes
- Reading-frame conservation, codon-substitution frequency
- Likelihood ratio framework: Estimating QCQN, scoring
- Revise genes, read-through, excess constraint regions
4. Signatures of RNAs, motifs, TFBS, microRNAs
- RNAs: Phylo-SCFGs. Motifs: MCS. TFBS: branch length
- miRNAs: Struct/evo. Comb: decision trees, random forests
- Sense/anti-sense miRNAs, mature/star arm cooperation
5. Measuring selection within the human lineage
Sentinel Indexing in Progress
Metadata and chapters are available. Claim extraction for this episode is pending.
All video content is delivered via YouTube embedded players in accordance with the YouTube Terms of Service. Sentinel provides research tools that promote discovery and accountability across political media.
