Manolis Kellis
@manoliskellis1·24.9K subscribers·255 videos
MIT CompBio Lecture 18 - Genome Evolution (Fall 2019)
Posted
November 7, 2019
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1,477
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November 7, 2019
1,477
30
1
2.10%
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1:21:02Now PlayingMIT Computational Biology: Genomes, Networks, Evolution, Health
Prof. Manolis Kellis
Full playlist with all videos in order is here
All slides from Fall 2019 are here
Outline for this lecture:
1. Foundations 1: Building the genome assembly
- Consensus-layout-overlap methods
- String graph methods
2. Foundations 2: Whole-genome alignment
- Resolving region correspondence
- Gene-based global genome alignment
- Mechanisms of rapid genome evolution
3. Evolutionary “jumps”: Whole genome duplication (WGD)
- Evolutionary signature of whole genome duplication
- Post-duplication emergence of new functions
4. Recent evolution 1: Human selection at multiple timescales
- Neutral evo, Hardy-Weinberg, Evidence of positive/directional selection
- Negative/purifying selection: SNP density, Derived allele freq, Heterozy.
5. Recent evolution 2: Human demographic history.
- History/evidence of migrations. Africa, India, Europe, Asia, Americas.
- Population size, dynamics, bottlenecks, expansion, effective pop size.
- Ancient DNA, Neanderthals, Denisovans. Gorilla/Chimp introgression.
6. Recent evolution 3: Human relatedness and ancestry painting
- 1000Genomes population differences. SNP sharing. IBD/heritability.
- Admixture, ancestry painting. PCA/MDS clustering (FST). PC correction
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