Manolis Kellis
@manoliskellis1·24.9K subscribers·255 videos
MIT CompBio Lecture 15 - eQTLs Mediation (Fall 2019)
Posted
October 30, 2019
Views
1,416
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October 30, 2019
1,416
13
0.92%
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1:18:37Now PlayingMIT Computational Biology: Genomes, Networks, Evolution, Health
Prof. Manolis Kellis
Full playlist with all videos in order is here
All slides from Fall 2019 are here
Outline for this lecture:
1. Motivations for mapping regulatory variants
2. Ex: Methylation QTLs in Alzheimer’s Disease
3. eQTL conceptual frameworks
4. eQTL discovery: methodologies
5. Insights on eQTL function and biology
- eQTL prevalence and impact
- eQTL positioning
- Reproducibility
- Tissue-specificity
- Gene annotation
- Co-regulation
- Trans-acting eQTL
- Disease-enrichment
- Directionality
- Disease-relevance
6. Allele-specific analysis
7. Mediation analysis & Bayesian inference
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