Manolis Kellis
@manoliskellis1·24.9K subscribers·255 videos
MIT CompBio Lecture 22 - Cancer Genomics
Posted
November 29, 2018
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November 29, 2018
13,585
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1:21:02Now Playing0. Introduction: oncogenes, tumor suppressors, hallmarks
- Hallmarks of cancer, tumor-suppressors, proto-oncogenes/oncogenes, mutator phenotype, oncoviruses, and fusion oncogenes.
1. Exome sequencing lessons: recurrence and heterogeneity
- Recurrence: common signatures across types/patients/tumors/clones
- Evolutionary dynamics: clonal heterogeneity, computational models
2. WGS lessons: non-coding drivers and convergence
- Background mutation rate: regions, chromatin states, patients, plexi
- Convergence: mutations = enhancers = genes = pathways
3. Beyond mutations: epigenomics, functional heterogeneity
- Epigenomic alterations: reprogramming
- Single-cell sequencing: functional heterogeneity
4. Tumor immunology, microenvironment, immunotherapy
- Tumor-microenvironment interactions, cancer immunoediting.
- Neo-antigens, immune suppression, immunotherapy.
Lecture 22 slides at:
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