Manolis Kellis
@manoliskellis1·24.9K subscribers·255 videos
MIT CompBio Lecture 15 - eQTLs
Posted
October 30, 2018
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October 30, 2018
5,312
77
4
1.52%
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1:21:22Now PlayingMIT Computational Biology: Genomes, Networks, Evolution, Health
Prof. Manolis Kellis
Fall 2018
Lecture 15 - eQTLs
1. Motivations for mapping regulatory variants
2. Ex: Methylation QTLs in Alzheimer’s Disease
3. eQTL conceptual frameworks
4. eQTL discovery: methodologies
5. Insights on eQTL function and biology
- eQTL prevalence and impact
- eQTL positioning
- Reproducibility
- Tissue-specificity
- Gene annotation
- Co-regulation
- Trans-acting eQTL
- Disease-enrichment
- Directionality
- Disease-relevance
6. Allele-specific analysis
7. Mediation analysis & Bayesian inference
Slides for Lecture 15:
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