Manolis Kellis
@manoliskellis1·24.9K subscribers·255 videos
MIT Compbio Lecture 16 - Heritability
Posted
November 1, 2018
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1,965
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November 1, 2018
1,965
26
1.32%
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1:18:34Now PlayingMIT Computational Biology: Genomes, Networks, Evolution, Health
Prof. Manolis Kellis
Fall 2018
Lecture 16 - Heritability
1. Heritability definition and key concepts:
- partitioning variance
- estimating variances
- narrow sense vs. broad sense
2. Genetic architecture of complex traits
- polygenic risk scores
- linear mixed models
- heritability partitioning
- omnigenic model of complex traits
- omnigenic model of complex traits
3. From genetic architectures to systems biology:
- rank-based enrichments
- genes, pathways, regulators
4. Phenotype prediction:
- imputing intermediate phenotypes
- large-scale models
- inference algorithms
Lecture 16 slides:
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