Dr John Kruse
@drjohnkruse·16.8K subscribers·484 videos
Is ADHD a Mitochondrial Disease?
Posted
July 31, 2025
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July 31, 2025
1,147
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17:47Now PlayingMain Chapters:
In the last few years, a host of mental health conditions (schizophrenia, depression, autism, dementia) have been attributed to mitochondrial dysfunction.
While mitochondrial dysfunction has been proposed to have a role in ADHD, we have somewhat less data than we do for some other conditions. Nevertheless, preliminary evidence has found signs of oxidative stress, mitochondrial dysfunction and genetic evidence to support a role for mitochondria in contributing to ADHD. We also have some very limited evidence that antioxidants (omega-3 fatty acids, pycnogenol, N-acetyl cysteine) can play a positive role in treating ADHD.
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Free link to my Medium Article on Mitochondria and ADHD:
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References:
Attention deficit-hyperactivity disorder suffers from mitochondrial dysfunction. Verma P, Singh A, Nthenge-Ngumbau DN, Rajamma U, Sinha S, Mukhopadhyay K, Mohanakumar KP.:
Mitochondrial Dysfunction in Attention Deficit Hyperactivity Disorder:
Oxidative Stress and ADHD: A Meta-Analysis:
Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder:
Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania:
Full Chapter list:
Streamed live May 31, 2023
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Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions.
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