Andrew Huberman
@hubermanlab·7.5M subscribers·510 videos
How Your Brain’s Reward Circuits Drive Your Choices | Dr. Robert Malenka
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July 10, 2023
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2:50:03Now PlayingIn this episode my guest is Robert Malenka, MD, PhD, a professor of psychiatry and behavioral sciences at Stanford School of Medicine who has made numerous seminal discoveries about how the brain changes (neuroplasticity) in response to learning and to rewarding and reinforcing experiences. We discuss the brain’s reward systems involving dopamine and serotonin and how they motivate us to seek out specific behaviors and substances. We discuss how these reward systems are modified based on context and our memories and how they can be hijacked toward maladaptive drug-seeking in addiction. We also explore how reward systems influence social connections, oxytocin and empathy and how that applies to our understanding of autism spectrum disorders. This episode should be of interest to those interested in neuroplasticity, social bonding, addiction, autism, learning and motivation.
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Dr. Robert Malenka
Stanford academic profile
Publications
Current clinical trial
Articles
Distinct neural mechanisms for the prosocial and rewarding properties of MDMA
Oxytocin receptor is not required for social attachment in prairie voles
Gating of social reward by oxytocin in the ventral tegmental area
Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia
Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin
Selective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin
Serotonin receptor regulation as a potential mechanism for sexually dimorphic oxytocin dysregulation in a model of Autism
5HT modulation of a medial septal circuit tunes social memory stability
Other Resources
Multidisciplinary Association for Psychedelic Studies (MAPS)
Timestamps
Title Card Photo CreditMike Blabac
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