Andrew Huberman
@hubermanlab·7.5M subscribers·510 videos
The Science of MDMA & Its Therapeutic Uses: Benefits & Risks | Huberman Lab Podcast
Posted
June 12, 2023
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June 12, 2023
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2:17:35Now PlayingIn this episode, I discuss methylenedioxymethamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder (PTSD), alcohol and other substance-use addictions. I discuss the neuronal mechanisms for how MDMA elevates mood, empathy, motivation, social engagement, and reduces “threat detection” and how these effects can synergistically support talk therapy. I also explain the ongoing debate about the potential neurotoxicity of MDMA, myths about the origins and treatments for post-MDMA “crash,” the evolving legal landscape around MDMA use for clinical purposes, and I caution recreational users about the extremely dangerous additives (e.g., fentanyl) now commonly found in black market MDMA. This should be of interest to those curious about MDMA, neuropharmacology, the origins of emotional processing in the brain, empathy, PTDS, neuroplasticity, mental health and psychiatry.
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Articles
A Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus
Effects of MDMA on sociability and neural response to social threat and social reward
The Effects of Acutely Administered 3,4Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen LevelDependent Resting State Functional Connectivity
Distinct neural mechanisms for the prosocial and rewarding properties of MDMA
Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans
RETRACTEDSevere Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA ("Ecstasy")
Science forced to retract article on “ecstasy”
Residual neurocognitive features of longterm ecstasy users with minimal exposure to other drugs
MDMAassisted therapy for severe PTSDa randomized, doubleblind, placebocontrolled phase 3 study
The effects of MDMAassisted therapy on alcohol and substance use in a phase 3 trial for treatment of severe PTSD
Books
PIHKALA Chemical Love Story
TraumaThe Invisible Epidemic
The Body Keeps the Score
Other Resources
Multidisciplinary Association for Psychedelic Studies (MAPS)
Participate in a MAPS trial
Huberman Lab episode on psilocybin
Huberman Lab episode on psychedelics for mental health
Huberman Lab episode on dopamine, mindset & drive
Huberman Lab episode on leveraging dopamine
Timestamps
Title Card Photo CreditMike Blabac
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