Dr John Kruse
@drjohnkruse·16.8K subscribers·484 videos
Weekly Q&A - Monoamine Oxidase Inhibitors and ADHD / Sunosi for ADHD?
Posted
July 9, 2025
Views
385
Likes
23
Comments
14
Engagement
9.61%
July 9, 2025
385
23
14
9.61%
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58:52Now PlayingJoin me for my Weekly Mental Health Recap and Q&A!
Livestream every Tuesday at 10:00am West Coast USA / 1:00pm East Coast USA / 7:00am Hawaii / 7:00pm Central European
Videos released this week:
- Monoamine Oxidase Inhibitors (MAOI) and ADHD
- Sunosi for ADHD?
After a 1 minute recap of each video, I’ll be available for questions on these topics or any other related to Mental Health.
- Monoamine Oxidase Inhibitors (MAOIs) and ADHD:
The ability of MAOIs to boost dopamine and norepinephrine make them appear to be a good fit for ADHD. But only a handful of studies, numbering less than 100 patients have explored the benefits of these drugs for those with ADHD. All of them looked at deprenyl/selegiline, which, in addition to being an MAOI, also is catabolized to methamphetamine and amphetamine. Most MAOIs also require some caution in use due to interactions with other medications and with certain foods.
- Sunosi for ADHD?:
Sunosi (solriamfetol) is a dopamine and norepinephrine reuptake inhibitor approved for treating daytime lethargy from narcolepsy or obstructive sleep apnea. Phase III studies support that it can be effective in addressing ADHD symptoms, and FDA approval (as of July 2025) is pending. Whether Sunosi will prove more effective for ADHD than Wellbutrin remains unknown.
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Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions.
Subscribe if you're curious about how neuroatypical brains can optimize their functioning in our shared, and somewhat strange, world.
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