Dr John Kruse
@drjohnkruse·16.8K subscribers·484 videos
Stimulants and Bone Health
Posted
March 21, 2026
Views
792
Likes
57
Comments
9
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8.33%
March 21, 2026
792
57
9
8.33%
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15:08Now PlayingMain Chapters:
Laboratory studies of rodents and human bone cells indicate that stimulant medications (amphetamine and methylphenidate) can disturb the functioning of bone cells, resulting in relatively more destruction than regeneration, leading over time to osteopenia and osteoporosis. But the evidence that this has a significant impact in either children or adults taking stimulant medications is much more meager and inconsistent. For most individuals, focusing on reducing other causes of osteoporosis (kidney or parathyroid disease, long term prednisone or antacid use, smoking, heavy alcohol intake, chronic sleep disturbances, poor diet, inadequate exercise) will lead to healthier bones than will altering their ADHD medication.
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Free link to my Medium article on Stimulants and Bones:
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References:
The Effects of Chronic Psychostimulant Administration on Bone Health: A Review (2024)
Complex interplay of neurodevelopmental disorders (NDDs), fractures, and osteoporosis: a mendelian randomization study (2024)
Psychostimulants Modafinil, Atomoxetine and Guanfacine Impair Bone Cell Differentiation and MSC Migration (2022)
Stimulant use and bone health in US children and adolescents: analysis of the NHANES data (2022)
Attention deficit hyperactivity disorder medications and bone mineral density of adults in the United States (2022)
ADHD associated with more severe and more frequent fractures (2014)
Attention deficit hyperactivity disorder and increased risk of injury (2009)
Full Chapter list:
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Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions.
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