Dr John Kruse
Dr John Kruse
@drjohnkruse·16.8K subscribers·467 videos

Modafinil - The Non-Stimulant Stimulant

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April 11, 2026

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Modafinil keeps people alert, but doesn't act as a stimulant. It helps with ADHD symptoms, and maybe depression as well. Should we be using it more often?

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Free link to my Medium article on Modafinil:

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References:

The Effect of Long-Acting Methylphenidate and Modafinil on Attention and Impulsivity of Children with ADHD using a Continuous Performance Test: A Comparative Study (2022)

Comparative efficacy and safety of stimulant-type medications for depression: A systematic review and network meta-analysis (2021)

Modafinil for the treatment of attention-deficit/hyperactivity disorder: A meta-analysis (2017)

FDA Clinical Review of Modafinil (including rejection for ADHD) (2006)

Full Chapter list:

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Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions.

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Guests & Subjects Covered

The Non-Stimulant StimulantMain Chapters IntroModafinil TakeModafinil HistoryModafinil ModafinilADHD Conclusion ModafinilModafinil FollowFull Medium

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